Cristina Legido-Quigley

Dr. Cristina Legido-Quigley serves as a Reader in Systems Medicine at the Institute of Pharmaceutical Science, King’s College London, where she leads research in neurometabolism and disease coping mechanisms. Additionally, she is the Head of the Systems Medicine research group at Steno Diabetes Center Copenhagen, focusing on personalized medicine in diabetes and metabolic diseases.

Favorite metabolite
Sphingomyelins are important in neuronal function, generally higher in women than men, and depleted in liver disease.

Papers discussed in this episode
Lipidomics and obesity
Huang et al. Nature 2024 Lipid profiling identifies modifiable signatures of cardiometabolic risk in children and adolescents with obesity

Lipidomics and Alzheimer’s disease in women
Wretlind et al. MedRxiv 2025 Lipid profiling reveals a deficit of lipids with unsaturated fatty acids in women with Alzheimer’s disease

Additional resources

Lipids in different body parts
Al-Sari et al. PLOSone 2020 Lipidomics of human adipose tissue reveals diversity between body areas

Baker Institute Lipidomics PheWeb
Genetic associations with the human lipidome discussed in the episode.

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Finally available – Alice’s first book
The STORY principle – A guide to the biological interpretation of metabolomics
Also featuring some of the Metabolomists from Season 1
Available on Amazon and the biocrates webshop