Ewy Mathé
She is the Director of Informatics in the Division of Preclinical Innovation at the National Center for Advancing Translational Sciences (NCATS), NIH, where she leads a highly creative and motivated team working to combine metabolomics, multi-omics and data science for translational research. Dr. Mathé and her team regularly release bioinformatics tools and guidance that support the scientific community in processing and integrating data for translational applications, including for drug repurposing, rare disease research, and multiomics integration. Projects discussed in this episode include the NCATS Biomedical Data Translator aimed at the integration of medical and biological data. Dr. Mathé is also the current President of the Metabolomics Association of North America (MANA) and a contributor to the Dagstuhl seminar 26181 on computational metabolomics.
Favorite metabolite
Creatine riboside
It is a metabolite of creatine from cancer cell metabolism. Learn more in the episode!
Papers discussed in the episode
Mathé et al. 2014 Cancer Research | Noninvasive Urinary Metabolomic Profiling Identifies Diagnostic and Prognostic Markers in Lung Cancer
Mathé et al. 2026 Current Opinion in Biotechnology | Computational metabolomics at scale: from open data to insight
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Finally available – Alice’s first book
The STORY principle – A guide to the biological interpretation of metabolomics
Also featuring some of the Metabolomists from Season 1
Available on Amazon and the biocrates webshop
Complement this episode with the perspectives of Julie Courraud on clinical metabolomics and study design and Justin van der Hooft on computational metabolomics and community-driven tools.
