Metabolomic epidemiology & childhood obesity

In this episode, Alice Limonciel and Sandi Azab discuss where metabolomics can provide maximum impact in epidemiology. They explore the surprising metabolic sex differences in childhood obesity that already exist in children under the age of five, discuss how to apply the fundamentals of epidemiology when designing metabolomics studies, and touch upon the importance of investigating ethnic diversity in precision medicine.

Sandi Azab

Sandi M Azab is Research Associate at McMaster University Department of Health Research Methods, Evidence and Impact in Canada.
Learn more about her work here. Connect with her here.

Favorite metabolite
Pentadecanoic acid (FA 15:0 or C15:0)

Papers discussed in this episode
Early sex-dependent differences in metabolic profiles of overweight and adiposity in young children: a cross-sectional analysis Sandi M Azab et al. BMC Med. 2023 | https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-02886-8

Systematic review discussed in the episode

A systematic review of metabolomic studies of childhood obesity: State of the evidence for metabolic determinants and consequences
Evangelos Handakas et al. Obesity Reviews. 2022 | https://onlinelibrary.wiley.com/doi/10.1111/obr.13384

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Finally available – Alice’s first book
The STORY principle – A guide to the biological interpretation of metabolomics
Also featuring some of the Metabolomists from Season 1
Available on Amazon and the biocrates webshop

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